Overview:

SMC1 is a member of the structural maintenance of chromosomes 1A family that is localized at the kinetochores and is involved in cell division. SMC1is part of the cohesin multiprotein complex which is required for sister chromatid cohesion (1). Most of the cohesin complexes dissociate from the chromosomes before mitosis but remain at the kinetochore and so SMC1 is an important part of the functional kinetochores. SMC1 protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair (2).

References:

1. Gruber, S. et al: Chromosomal cohesin forms a ring. Cell 112: 765-777, 2003.

2. Revenkova, E. et al: Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA. Hum. Molec. Genet. 18: 418-427, 2009.