Fyn C (Fyn isoform C) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn is a membrane-associated tyrosine kinase involved in the control of cell growth and can interact with Fyn-binding protein and the p85 subunit of PI3K (1). Fyn has been shown to be part of a protein complex involving DCC and FAK which is downstream of Netrin-1, a pathway important in promoting both axonal outgrowth and axonal guidance in path finding (2).
SLK, SYN, MGC45350
1. Semba, K. et al: yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc. Nat. Acad. Sci. 83: 5459-5463, 1986.
2. Li, W. et al: Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nature Neurosci. 7: 1213-1221, 2004.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
A Binolfi et al., Intracellular repair of oxidation-damaged [alpha]-synuclein fails to target C-terminal modification sites Nature Communications January 2016 10.1038/ncomms10251
Y Yamazaki et al., Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. Neuropharmacology October 2016 10.1016/j.neuropharm.2016.10.021
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology