Rabbit Polyclonal Antibody
Catalog No. S03-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S03-63R-100 | 100 ug | $455 | |
S03-63R-BULK | BULK | Contact Us |
Overview:
SH2D1A contains an SH2 domain and a short tail, and expresses at a high level in thymus and lung. It acts as an inhibitor of the SLAM (signaling lymphocyte-activation molecule) proteins by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. It modifies signal transduction pathways in activated T, B and NK cells. SH2D1A mediates interaction between FYN and SLAMF1 (1). Mutations in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) (2).
References:
1. Chan B., et al: SAP couples Fyn to SLAM immune receptors. Nat. Cell Biol. 5:155-160(2003)
2. Dutz, J. P., et al: Lymphocytic vasculitis in X-linked lymphoproliferative disease. Blood 97: 95-100, 2001.
Specificity:
Recognizes the SH2D1A (SAP) protein
Cross Reactivity:
Western blot human SH2D1A (SAP)
SH2D1A (SAP) from other species may also be detectable.
Host :
Rabbit
Immunogen:
Synthetic peptide corresponding to amino acids 113-128 of human SH2D1A (SAP)
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Representative Western blot with Anti-SH2D1A (SAP) (1:1000) using 15 μg, 30 μg and 60 μg of Jurkat cell lysate.
There are no related publications available for this product.
Inflammation
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