Overview:

As the best characterized binding motif for lysine acetylation, Bromodomains (BRDs) are 110 amino acid highly conserved modules found in transcriptional co-regulators, chromatin modifying enzymes and nuclear scaffold proteins. Initially identified in the protein encoded by the D. melanogaster brahama gene. Along with BRD2, BRD4 and BRDT, Bromodomain-containing protein 3 (BRD3) lacks intrinsic chromatin modifying potential and primarily function as scaffolds for transcription factors or other chromatin regulating factors. It is characterized by the presence of two distinct BRDs at the N-terminal end of the protein. BRD3 is involved in the pathognomonic chromosomal translocations seen in NUT midline carcinoma (NMC).

Gene Aliases:

KIAA0043; ORFX; RING3L

Genbank Number:

NM_007371

References:

1. French CA, et al: BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 63(2):304-7, 2003.

2. Barbieri I, et al: Bromodomains as therapeutic targets in cancer. Brief Funct Genomics. 12(3):219-30, 2013.