Overview:

DGKH is a type II DGK encoded by gene DGKH (1). Diacylglycerol kinases modulate the concentration of intracellular diacylglycerol by phosphorylating, producing phosphatidic acid (PA) (2). PA regulates signaling proteins, such as protein kinases and phosphatases, and can induce cell mitosis through regulation of growth factors (3). DGKH is a positive regulator of the epidermal growth factor receptor/Raf/MEK/ERK pathway. DGKH is associated with attention deficit hyperactivity disorder, unipolar depression and schizophrenia (4).

Gene Aliases:

Diacylglycerol kinase eta; Diglyceride kinase eta

Genbank Number:

NM_178009.5

References:

1. Rittiner, JE. et al: Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling. Mol Pharmacol. 2014; 85(5):800-810.

2. Ding, L. et al: The cloning and characterization of a novel human diacylglycerol kinase, DGKiota. J Biol Chem. 1998; 273(49):32746-52.

3. Buckland, AG. et al: Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim Biophys Acta. 2000; 1483(2):199-216.

4. Sakane, F. et al: Diacylglycerol kinases as emerging potential drug targets for a variety of diseases: An update. Front Cell Dev Biol. 2016; 4:82.