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CASK, Active

Recombinant human CASK (1-570) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C19-11G


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Catalog No. Pack Size Price (USD)
C19-11G-05 5 ug $226
C19-11G-10 10 ug $325
C19-11G-BULK BULK Contact Us  


Overview:

CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member (1). CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton (2).


Gene Aliases:

CAGH39; CAMGUK; CMG; FGS4; LIN2; MICPCH; TNRC8


Genbank Number:


References:


1. Atasoy, D.et.al: Deletion of CASK in mice is lethal and impairs synaptic function. Proc. Nat. Acad. Sci. 104: 2525-2530, 2007.

2. Cohen, A. R. et.al: Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J. Cell Biol. 142: 129-138, 1998.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~95 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases


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