Overview:

Retinoblastoma-binding protein 5 (RBBP5) is believed to play a crucial role in the differentiation potential, particularly along the neural lineage in embryonic stem (ES) cells, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and tri-methylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.

Gene Aliases:

RBQ3; SWD1

Genbank Number:

NM_005057

References:

1. Thttp://www.uniprot.org/uniprot/Q15291

2. Patel A, et al: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem. 2009; 284(36):24242-56.