Recombinant full-length human PRMT7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P365-30GG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P365-30GG-20 | 20 ug | $314 | |
P365-30GG-50 | 50 ug | $545 | |
P365-30GG-BULK | BULK | Contact Us |
Overview:
PRMT7 (protein arginine methyltransferase 7), an arginine methyltransferase that exhibited type III enzymatic activity, catalyzing the formation of ω-NG-monomethylarginine residues. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency.
Gene Aliases:
FLJ10640, KIAA1933
Genbank Number:
References:
1. Miranda TB, et al: PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. J Biol Chem. 279(22):22902-7, 2004.
2. Lee JH, et al: PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine. J Biol Chem. 280(5):3656-64, 2005.
3. http://www.uniprot.org/uniprot/Q9NVM4
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
110 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology
STAY CONNECTED
Fax: 1-604-232-4601