Overview:

PCMT1 is a member of the L-isoaspartyl/D-aspartyl protein methyltransferase family, which plays an important role in protein repair (1). Downregulation of PCMT1 leads to hyperactivation of MAPK pathway upon EGF stimulation (2). PCMT1 is regulated by cell-matrix interactions, and linked to various biological processes including wound healing, cell migration, and tumor metastasis (3).

Gene Aliases:

None

Genbank Number:

BC007501

References:

1. Tsai, W., et al. Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair. Biochem Biophys Res Commun. 203(1):491-7, 1994.

2. Kosugi, S., et al. Suppression of protein l-isoaspartyl (d-aspartyl) methyltransferase results in hyperactivation of EGF-stimulated MEK-ERK signaling in cultured mammalian cells. Biochem Biophys Res Commun. 371(1):22-7, 2008.

3. Lanthier, J., et al. Regulation of protein L-isoaspartyl methyltransferase by cell-matrix interactions: involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome. Biochem Cell Biol. 84(5):684-94, 2006.