Overview:

KAT3B (also known as EP300) encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein that functions as a histone acetyltransferase. KAT3B regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. KAT3B binding is a highly accurate process and can be used for identifying enhancers and their associated activities (1). KAT3B is also useful in the study of the role of tissue-specific enhancers in human biology and diseases on a genome wide scale. Defects in KAT3B gene are a cause of Rubinstein-Taybi syndrome that play a important role in epithelial cancer and act as a classic tumor suppressor gene (2).

Gene Aliases:

KAT3B; EP300; p300

Genbank Number:

NM_001429

References:

1. Visel, A. et.al: ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457: 854-858, 2009.

2. Gayther, S. A. et.al: Mutations truncating the EP300 acetylase in human cancers. Nature Genet. 24: 300-303, 2000.