Recombinant human KAT3A (518-1207) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K312-31G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
K312-31G-20 | 20 ug | $215 | |
K312-31G-50 | 50 ug | $435 | |
K312-31G-BULK | BULK | Contact Us |
Overview:
KAT3A has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. KAT3A (CREBBP) expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. KAT3A plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition (1). KAT3A also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus (2).
Gene Aliases:
CREBBP; CBP; KAT3A; RSTS
Genbank Number:
References:
1. Arias, J. et.al: Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370: 226-229, 1994.
2. Kasper, L. H. et.al: A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419: 738-743, 2002.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~140 kDa
Sehgal Lalit et al., 14-3-3γ-mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo Cell Science May 2014 10.1242/jcs.125807
AW Sorum et al., Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors. ACS Chemical Biology March 2016 10.1021/acschembio.5b00709
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway
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