Home   >    Proteins   >   Signaling Proteins

p27KIP1 Protein

Recombinant full-length human p27KIP1 was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. C28-30G


Shop Online



Catalog No. Pack Size Price (USD)
C28-30G-50 50 ug $435
C28-30G-20 20 ug $215
C28-30G-BULK BULK Contact Us  


Overview:

KIP1 (cyclin-dependent kinase inhibitor 1B) is a kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation (1). Many tumorigenic processes modulate cell-cycle progression by regulating the levels of the cyclin-dependent kinase inhibitor KIP1. KIP1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (2). The phosphorylation- and ubiquitination-dependent proteolysis of KIP1 is implicated in control of the G1-S transition in the cell cycle. KIP1 is critical for retinoblastoma protein (Rb)-induced cellular proliferative senescence.


Gene Aliases:

CDKN1B, CDKN4, MEN1B


Genbank Number:


References:


1. Hoyt, M A. et al: Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 1992 118(1):109-120.

2. Carrano,A C. et al: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1999; 1, 193-199


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~52 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  p18INK4C Protein, C32-30G

  CDK3/CyclinE1, Active, C30-10G

  CDK2/CyclinE1, Unactive, C29-14G

  CDK2, Unactive, C29-14BG


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox