Home   >    Proteins   >   Signaling Proteins

Cyclin E2 Protein

Recombinant full-length human CyclinE2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C82-30BG


Shop Online



Catalog No. Pack Size Price (USD)
C82-30BG-20 20 ug $314
C82-30BG-50 50 ug $435
C82-30BG-BULK BULK Contact Us  


Overview:

CCNE2 is belongs to the cyclin family, Cyclin E subfamily. It is encoded by a separate gene from Cyclin E1, but shows substantial amino acid sequence similarity. Like Cyclin E1, it binds and activates the cyclin-dependent kinase 2 (Cdk2), which in turn phosphorylates proteins involved in cell cycle progression such as pRB, p107, NPM1, MCMs, thereby driving cell proliferation. A defect in spermatogenesis is the only phenotype observed in cyclin E2-deficient mice, suggesting its role in male fertility.


Gene Aliases:

CCNE2; CYCE2


Genbank Number:


References:


1. Geng Y, et al. (2003) Cyclin E ablation in the mouse. Cell 114: 431–443.

2. Hwang HC, et al. (2005) Cyclin E in normal and neoplastic cell cycles. Oncogene 24: 2776–2786.

3. Odajima J, et al. (2016). Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. PLoS Genet. 12(11):e1006429.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

72 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  CDK4/CyclinD1, Active, C31-10G

  CyclinC Protein, C80-30G

  CyclinO Protein, C85-30G

  Cyclin Y Protein, C87-30G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox