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p16INK4A Protein

Recombinant full-length human p16INK4A was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. C30-30G


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Catalog No. Pack Size Price (USD)
C30-30G-20 20 ug $215
C30-30G-50 50 ug $435
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Overview:

p16INK4A protein family specifically inhibit cyclin-dependent kinase 4-mediated phosphorylation of the retinoblastoma (Rb) susceptibility gene product. p16INK4A, has been identified as a tumor suppressor in many human cancers and inactivation of p16INK4A in tumors is thought to be required in order for many malignant cell types to enter S-phase (1). p16INK4A expression is required for the reduction in cdk4- and cdk6-mediated Rb kinase activity observed in response to DNA damage. p16INK4A gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene (2).


Gene Aliases:

CDKN2A, ARF, MLM, p14, p16, p19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4a, p14ARF, p16INK4


Genbank Number:


References:


1. Smith-Sørensen, B. et al: CDKN2A (p16INK4A) somatic and germline mutations. Hum. Mutat. 1996; 7 (4): 294-303.

2. Kusy, S. et al: p14ARF, p15INK4b and p16INK4a methylation status in chronic myelogenous leukemia. Leuk, Lymphoma, 2005; 45 (10): 1989-94.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

41 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  p15INK4B Protein, C31-30G

  p19INK4D Protein, C33-30G

  p18INK4C Protein, C32-30G


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