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CyclinD3 Protein

Recombinant full-length human CyclinD3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C81-30B3G


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Catalog No. Pack Size Price (USD)
C81-30B3G-20 20 ug $215
C81-30B3G-50 50 ug $435
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Overview:

CyclinD3 protein is a member of the D-type cyclins. D-type cyclins are regulators of cell cycle and interact with several transcription factors modulating their transcriptional activations. CyclinD3 forms a complex and functions as a regulatory subunit of CDK4 or CDK6 that regulates the cell-cycle during G1/S transition. The complex also regulates the G1 restriction point of cell cycle via phosphorylating the retinoblastoma protein, which is a tumor suppressor protein. (1) Therefore, abnormal expression of CyclinD3 has been associated with tumorigenesis. Abnormal expression of CyclinD3 is observed in bladder carcinoma and several human B-lymphoid malignancies. (2)


Gene Aliases:

None


Genbank Number:


References:


1. Lui, W. et al: Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. Biochem Biophys Res Commun. 321(4): 954-960, 2004.

2. Chi, Y. et al. Cyclin D3 predicts disease-free survival in breast cancer. Cancer Cell Int. 15, 89, 2015.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

58 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  CDK11A (CDC2L2)/CyclinD3 Protein, C24-35CG

  CDK6/CyclinD3, Unactive, C35-14H

  CyclinC Protein, C80-30G


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