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p63 Protein

Full-length recombinant human p63 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Catalog No. P06-30G


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Catalog No. Pack Size Price (USD)
P06-30G-50 50 ug $435
P06-30G-20 20 ug $215
P06-30G-BULK BULK Contact Us  


Overview:

p63 is the primordial member of the p53 family that acts in a conserved process of monitoring the integrity of the female germline, whereas the functions of p53 are restricted to vertebrate somatic cells for tumor suppression. p63 protein plays an important role in the development and maintenance of stratified epithelial tissues (1). p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis (2). Mutations in p63 are associated with ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3) and split-hand/foot malformation 4 (SHFM4).


Gene Aliases:

TP63; AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L


Genbank Number:


References:


1. Yang, A., Schweitzer, R. et.al: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398: 714-718, 1999.

2. Suh, E.-K. et.al: p63 protects the female germ line during meiotic arrest. Nature 444: 624-628, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~92 kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, p38 Pathway


RELATED PRODUCTS


  p53 Protein, P05-30BG

  p53 Protein, P05-30G

  Anti-p53, P05-63R

  p73 beta Protein, P08-30BG


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