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p73 alpha Protein

Full-length recombinant human p73 alpha was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Catalog No. P08-30G


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Catalog No. Pack Size Price (USD)
P08-30G-50 50 ug $435
P08-30G-20 20 ug $215
P08-30G-BULK BULK Contact Us  


Overview:

p73α is a member of the p53 family of transcription factors that are involved in cellular responses to stress and development. P73 has high sequence similarity to p53 and p63, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. P73 is a stress-response gene and a downstream effector in the p53 pathway (1). The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. p73 is the components of a mismatch repair-dependent apoptosis pathway which contributes to cisplatin-induced cytotoxicity (2).


Gene Aliases:

TP73, TAp73alpha


Genbank Number:


References:


1. Wang, J. et.al: p73 is a downstream target of p53 in controlling the cellular defense against stress. J. Biol. Chem. 282: 29152-29162, 2007.

2. Gong, J. et.al: The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809, 1999.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, p38 Pathway


RELATED PRODUCTS


  p63 Protein, P06-30G

  p53 Protein, P05-30BG

  Anti-p53, P05-63R

  p73 gamma Protein, P08-30CG


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