Overview:

p73α is a member of the p53 family of transcription factors that are involved in cellular responses to stress and development. P73 has high sequence similarity to p53 and p63, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. P73 is a stress-response gene and a downstream effector in the p53 pathway (1). The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. p73 is the components of a mismatch repair-dependent apoptosis pathway which contributes to cisplatin-induced cytotoxicity (2).

Gene Aliases:

TP73, TAp73alpha

Genbank Number:

NM_005427

References:

1. Wang, J. et.al: p73 is a downstream target of p53 in controlling the cellular defense against stress. J. Biol. Chem. 282: 29152-29162, 2007.

2. Gong, J. et.al: The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809, 1999.