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p73 beta Protein

Full-length recombinant human p73 beta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P08-30BG


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Catalog No. Pack Size Price (USD)
P08-30BG-50 50 ug $435
P08-30BG-20 20 ug $215
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Overview:

p73β is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. P73β is strongly involved in malignancy acquisition and maintenance (1). p73 is a stress-response gene that activates transcription of p53-responsive genes and inhibits cell growth in a p53-like manner by inducing apoptosis (2). p73 is a component of a mismatch repair-dependent apoptosis pathway, which contributes to cisplatin-induced cytotoxicity. The regulation of p73 by c-Abl in response to DNA damage was also demonstrated by a failure of ionizing radiation-induced apoptosis after disruption of c-Abl-p73 interaction.


Gene Aliases:

TP73, TAp73beta


Genbank Number:


References:


1. Jost. C. A. et.al: p73 is a human p53-related protein that can induce apoptosis. Nature 389: 191-194, 1997.

2. Gong, J. et.al: The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809, 1999.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~88 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, p38 Pathway


RELATED PRODUCTS


  p63 Protein, P06-30G

  p53 Protein, P05-30G

  Anti-p53, P05-63R

  p73 gamma Protein, P08-30CG


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