Home   >    Proteins   >   Signaling Proteins

CDK5P25 Protein

Recombinant human CDK5P25 (CDK5R1) (98-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C34-31G


Shop Online



Catalog No. Pack Size Price (USD)
C34-31G-20 20 ug $215
C34-31G-50 50 ug $435
C34-31G-BULK BULK Contact Us  


Overview:

CDK5P25 (cyclin-dependent kinase 5, regulatory subunit 1) is a neuron-specific activator of CDK5 and is required for proper development of the central nervous system (1). The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form of the protein which relocates from the cell periphery to nuclear and perinuclear regions. CDK5P25 regulates CDK5 activity by prolonging its activation and changing its cellular location and this may be important in pain signaling (2). The CDK5P25 accumulates in the brain neurons of patients with Alzheimer's disease and this accumulation correlates with an increase in CDK5 kinase activity which may result in aberrantly phosphorylated forms of the microtubule-associated protein tau.


Gene Aliases:

p25, CDK5R1, CDK5R, NCK5A, p23


Genbank Number:


References:


1. Tsai, L.-H.et.al: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371: 419-423, 1994.

2. Pareek, T. K.et.al: Cyclin-dependent kinase 5 activity regulates pain signaling. Proc. Nat. Acad. Sci. 103: 791-796, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~49 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  CyclinA2 Protein, C78-30BG

  CDK5P35 Protein, C34-30G

  CyclinE1 Protein, C82-30G

  CDK2/CyclinO, Active, C29-19G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox