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p33ING2 Protein

Recombinant full-length human p33ING2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I32-30BG


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Catalog No. Pack Size Price (USD)
I32-30BG-20 20 ug $215
I32-30BG-50 50 ug $435
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Overview:

p33ING2 is a member of the inhibitor of growth (ING) family that is associate with and modulates the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. P33ING2 is a DNA damage-inducible gene that negatively regulates cell proliferation through activation of p53 by enhancing its acetylation (1). P33ING2 is required for initial DNA damage sensing and chromatin remodeling in the nucleotide excision repair process (2).


Gene Aliases:

ING1L, ING2


Genbank Number:


References:


1. Nagashima, M.et.al: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc. Nat. Acad. Sci. 98: 9671-9676, 2001.

2. Wang, J.et.al: The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. Cancer Res. 66: 1906-1911, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~62 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  p33ING1 Protein, I32-30H


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