p33ING2 is a member of the inhibitor of growth (ING) family that is associate with and modulates the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. P33ING2 is a DNA damage-inducible gene that negatively regulates cell proliferation through activation of p53 by enhancing its acetylation (1). P33ING2 is required for initial DNA damage sensing and chromatin remodeling in the nucleotide excision repair process (2).
1. Nagashima, M.et.al: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc. Nat. Acad. Sci. 98: 9671-9676, 2001.
2. Wang, J.et.al: The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. Cancer Res. 66: 1906-1911, 2006.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cell Cycle