Overview:

p33ING2 is a member of the inhibitor of growth (ING) family that is associate with and modulates the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. P33ING2 is a DNA damage-inducible gene that negatively regulates cell proliferation through activation of p53 by enhancing its acetylation (1). P33ING2 is required for initial DNA damage sensing and chromatin remodeling in the nucleotide excision repair process (2).

Gene Aliases:

ING1L, ING2

Genbank Number:

NM_001564

References:

1. Nagashima, M.et.al: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc. Nat. Acad. Sci. 98: 9671-9676, 2001.

2. Wang, J.et.al: The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. Cancer Res. 66: 1906-1911, 2006.