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CyclinH Protein

Recombinant full length human Cyclin H was expressed in insect cells using an N-terminal His tag.
Catalog No. C83-30H


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Catalog No. Pack Size Price (USD)
C83-30H-20 20 ug $215
C83-30H-50 50 ug $435
C83-30H-BULK BULK Contact Us  


Overview:

Cyclin H is related to the highly conserved cyclin family. Cyclin family members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Cyclin H forms a complex with CDK7 kinase and the ring finger protein MAT1 which is able to phosphorylate CDK2 and CDC2 kinases and thus act as a CDK-activating kinase (CAK) (1). Cdk-activating kinase complex is a component of human transcription factor TFIIH and plays an important role in the processes of transcription, DNA repair, and cell cycle progression (2).


Gene Aliases:

CCNH; CAK; p34; p37


Genbank Number:


References:


1. Eki, T. et.al: Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. Genomics 47: 115-120, 1998.

2. Shiekhattar, R. et.al: Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374: 283-287, 1995.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~39 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  CDK2/CyclinA1, Active, C29-10BG

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  CDK9/CyclinK, Active, C40-10G

  Cyclin T2 Protein, C86-30BG


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