Demethylase Inhibitor
Catalog No. K421-904
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K421-904-50 | 50 mg | $60 | |
| K421-904-250 | 250 mg | $225 | |
| K421-904-BULK | BULK | Contact Us |
Overview:
Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50 < 2 uM1,2. Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of exogenous Sox23. Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells4. Upregulates CD86 expression in THP1 cells5. Cell permeable and active in vivo.
References:
1. NG Lee et al. Chem. Biol. 2006 13:563
2. DM Schmidt and DG McCafferty Biochemistry 2007 46:4408
3. W Li et al. Stem Cells 2009 27:2992
4. D Ding et al. Fertil. Steril. 2014 101:740
5. JT Lynch et al. Anal. Biochem. 2013 442:104
CAS Registry Number:
13492-01-8
Molecular Formula:
C9H11N · 1/2H2SO4
Appearance:
White powder
Molecular Weight:
182.2
Purity:
>98% (TLC)
Solubilization:
May be dissolved in water (25 mg/ml)
Aliases:
Trans (±)-2-phenylcyclopropanamine; 2-PCPA
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
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