Histone Methyl Transferase Inhibitor
Catalog No. S344-903
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| S344-903-5 | 5 mg | $90 | |
| S344-903-25 | 25 mg | $360 | |
| S344-903-BULK | BULK | Contact Us |
Overview:
BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 uM) as well as GLP HMTase (IC50 = 38 uM) leading to a decrease in H3K9Me2 (histone H3 lysine 9 methylation) in vitro1. It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming2. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells3. It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells4.
References:
1. S Kubicek et al. Mol. Cell 2007 25:473
2. D Huangfu et al. Nat. Biotechnol. 2008 26:795
3. Y Shi et al. Cell Stem Cell 2008 2:525
4. Z Lu et al. Anticancer Drugs 2013 24:484
CAS Registry Number:
935693-62-2
Molecular Formula:
C28H38N6O2.3HCl
Appearance:
Off-white crystalline powder
Molecular Weight:
600.02
Purity:
>98%
Solubilization:
May be dissolved in water (50 mg/ml) or DMSO (50 mg/ml)
Aliases:
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
Storage and Stability:
Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology
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