CAMKK inhibitor
Catalog No. C17-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C17-900-05 | 5 mg | $105 | |
| C17-900-25 | 25 mg | $360 | |
| C17-900-BULK | BULK | Contact Us |
Overview:
Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively). Binds to the ATP-binding site. Displays >80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Cell permeable.
References:
1. H Tokumitsu et al. J. Biol. Chem. 2002 277:15813
2. H Tokumitsu et al. J. Biol. Chem. 2003 278:10908
CAS Registry Number:
52029-86-4
Molecular Formula:
C19H10N2O3 ∙ CH3COOH
Appearance:
Yellow powder
Melting Point:
N/A
Molecular Weight:
314.3
Purity:
98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in: DMSO (10 mg/ml)
Aliases:
7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases
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