Recombinant human WHSC1 (911-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N377-381G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N377-381G-05 | 5 ug | $259 | |
| N377-381G-10 | 10 ug | $380 | |
| N377-381G-100 | 100 ug | $2283 | |
| N377-381G-BULK | BULK | Contact Us |
Overview:
Histone-lysine N-methyltransferase NSD2 or Multiple myeloma SET domain-containing protein (MMSET) is a histone methyltransferase (HMT) with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Overexpressed in t(4;14)+ multiple myeloma (MM) patients, leading to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in histone 3 lysine 27 trimethylation (H3K27me3), accompanied by changes in proliferation, gene expression and chromatin accessibility.
Gene Aliases:
MMSET; WHSC1; REIIBP; TRX5; WHS
Genbank Number:
References:
1. Shah MY, et al: MMSET/WHSC1enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.116.
2. Morishita M, et al: Cancers and the NSD family of histone lysine methyltransferases. Biochim Biophys Acta. 2011 Dec;1816(2):158-63.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
80 kDa
There are no related publications available for this product.
Cancer, NfkB Pathway
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