Recombinant human Rb (773-928) was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. R05-55G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R05-55G-20 | 20 ug | $215 | |
R05-55G-50 | 50 ug | $435 | |
R05-55G-BULK | BULK | Contact Us |
Overview:
Rb is the retinoblastoma gene product and was the first tumor suppressor cloned. Rb is a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase (1). Rb can bind to MDM2 and this overcomes both the antiapoptotic function of MDM2 and the MDM2-dependent degradation of p53. Rb associates with the Polycomb group (PcG) proteins to form a repressor complex that blocks entry of cells into mitosis (2). Rb colocalizes with nuclear PcG complexes and is important for association of PcG complexes with nuclear targets.
Gene Aliases:
RB1, OSRC
Genbank Number:
References:
1. Hanahan, D.et al: The hallmarks of cancer. Cell 100: 57-70, 2000.
2. Dahiya, A. et al: Linking the Rb and Polycomb pathways. Molec. Cell 8: 557-568, 2001.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~44 kDa
Liu Haidan et al., A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases Journal of Biological Chemistry September 2013 10.1074/jbc.M113.464669
et al., Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway. Nature cell biology June 2018
et al., Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity Cell chemical biology June 2020
Cancer, Cell Cycle, Neurobiology
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