p63 Protein
Full-length recombinant human p63 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Catalog No. P06-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P06-30G-20 | 20 ug | $215 | |
| P06-30G-50 | 50 ug | $435 | |
| P06-30G-BULK | BULK | Contact Us |
Full-length recombinant human p63 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Catalog No. P06-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P06-30G-20 | 20 ug | $215 | |
| P06-30G-50 | 50 ug | $435 | |
| P06-30G-BULK | BULK | Contact Us |
Overview:
p63 is the primordial member of the p53 family that acts in a conserved process of monitoring the integrity of the female germline, whereas the functions of p53 are restricted to vertebrate somatic cells for tumor suppression. p63 protein plays an important role in the development and maintenance of stratified epithelial tissues (1). p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis (2). Mutations in p63 are associated with ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3) and split-hand/foot malformation 4 (SHFM4).
Gene Aliases:
TP63; AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L
Genbank Number:
References:
1. Yang, A., Schweitzer, R. et.al: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398: 714-718, 1999.
2. Suh, E.-K. et.al: p63 protects the female germ line during meiotic arrest. Nature 444: 624-628, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~92 kDa
A. Hilton Benjamin et al., ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1 Molecular Cell October 2015 10.1016/j.molcel.2015.08.008
Ling Chau Jenny Fung et al., A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response Nature Communications May 2012 10.1038/ncomms1832
A Serrano M et al., DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair Oncogene May 2013 10.1038/onc.2012.257
Graczyk Agnieszka et al., S100A6 Competes with the TAZ2 Domain of p300 for Binding to p53 and Attenuates p53 Acetylation Journal of Molecular Biology September 2013 10.1016/j.jmb.2013.06.007
Chen Dongshi et al., TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity Oncotarget September 2014 10.18632/oncotarget.2440
S Mondal et al., A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Analytical Biochemistry October 2016 10.1016/j.ab.2016.06.016
Li Zhengke et al., Cytoplasmic ATR Lacking Checkpoint Kinase Activity is a BAX-Inhibiting Antiapoptosis Protein at Mitochondria Thesis December 2013
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, p38 Pathway
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