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SYVN1 (HRD1) Protein

Recombinant human SYVN1 (HRD1) (226-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S284-31G

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Catalog No. Pack Size Price (USD)
S284-31G-20 20 ug $314
S284-31G-50 50 ug $545
S284-31G-BULK BULK Contact Us  


Synoviolin (SYVN1/HRD1) is a multispanning membrane protein with its C-terminal RING-H2 finger domain located in the cytoplasm. A member of the E3 ubiquitin-protein ligase family that accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, acting as a part of the ER-associated degradation (ERAD) system involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.

Gene Aliases:

SYVN1 (synoviolin); HRD1; DER3

Genbank Number:


1. Nadav E, et al: A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem Biophys Res Commun. 2003 303(1):91-7.

2. Kikkert M, et al: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J Biol Chem. 2004 279(5):3525-34.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~80 kDa

Product Datasheets

There are no related publications available for this product.


Cancer, Cellular Stress, Inflammation, Neurobiology



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