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PHKG1, Active

Recombinant full-length human PHKG1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P19-10G


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Catalog No. Pack Size Price (USD)
P19-10G-05 5 ug $226
P19-10G-10 10 ug $325
P19-10G-BULK BULK Contact Us  


Overview:

PHKG1 or phosphorylase kinase gamma 1 is a member of the Ser/Thr protein kinase family that encodes a protein with one protein kinase domain and two calmodulin-binding domains. Phosphorylase kinase is a crucial glycogenolytic regulatory enzyme (1). PHKG1 is the catalytic member of a 16-subunit protein kinase complex that contains equimolar ratios of 4 subunit types known as alpha, beta, gamma and delta (2). Skeletal muscle contains the highest amount of phosphorylase kinase enzymatic activity, although activity is also observed in liver, cardiac muscle, brain, and several other tissues.


Gene Aliases:

PHKG


Genbank Number:


References:


1. Burwinkel, B. et.al: Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases. Europ. J. Hum. Gen. 11: 516-526, 2003.

2. Wehner, M. et.al: Human cDNA encoding the muscle isoform of the phosphorylase kinase gamma subunit (PHKG1).


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~70 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Metabolic Disorder, Ser/Thr Kinases


RELATED PRODUCTS


  PHKG2, Active, P20-10G


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