Specificity:

Recognizes the JAK2 protein phosphorylated at tyrosine 1007

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 1007 (K-E-YP-Y-K).

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-JAK2 (Tyr1007).

References :

1. Lacronique, V. Et al: A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science, 1997; 278: 1309-1312.

2. Ho, J.M. et al: TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways. Blood, 2002; 100: 1438-1448.

3. James C, et al. (2005) Nature. 434(7037): 1144-1148. Argetsinger LS, et al. (2004) Mol Cell Biol. 24(11): 4955-4967.

4. Ungureanu D, et al. (2002) Mol Cell Biol. 22(10): 3316-3326. Xie S, et al. (2001) Oncogene. 20(43): 6188-6195.