Anti-phospho-TRKA (Ser791)
Rabbit Polyclonal Antibody
Catalog No. N16-65R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N16-65R-100 | 100 ug | $325 | |
| N16-65R-BULK | BULK | Contact Us |
Rabbit Polyclonal Antibody
Catalog No. N16-65R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N16-65R-100 | 100 ug | $325 | |
| N16-65R-BULK | BULK | Contact Us |
Overview:
TRKA is a member of the TRK proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2).
References:
1. Kaplan, D R. et al: The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991 Apr 26;252(5005):554-8.
2. Boissiere, F. et al: Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):219-23.
Specificity:
Recognizes the TRKA protein phosphorylated at serine 791
Cross Reactivity:
Human
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
The antibody was produced against synthesized phosphopeptide derived from human TrkA around the phosphorylation site of tyrosine791 (P-V-YP-L-D).
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Immunofluorescence staining of methanol-fixed HeLa cells using Anti-phospho-TRKA (Ser791).
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Krejci Pavel et al., NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells Journal of Biological Chemistry July 2010 10.1074/jbc.M109.083626
Krejci Pavel et al., Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation PLoS One April 2012 10.1371/journal.pone.0035826
Neurobiology, Receptor Tyrosine Kinases
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