Anti-Phospho-MARK2 (Thr595)
Rabbit Polyclonal Antibody
Catalog No. M44-65R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M44-65R-100 | 100 ug | $675 | |
| M44-65R-BULK | BULK | Contact Us |
Rabbit Polyclonal Antibody
Catalog No. M44-65R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M44-65R-100 | 100 ug | $675 | |
| M44-65R-BULK | BULK | Contact Us |
Overview:
MARK2 or microtubule affinity-regulating kinase 2 is a member of the Par-1 family of serine/threonine protein kinases. MARK2 is an important regulator of cell polarity in epithelial and neuronal cells and controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins (1). MARK2 is a key target of H. pylori CagA in the disorganization of gastric epithelial architecture underlying mucosal damage, inflammation, and carcinogenesis (2). MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. MARK2 function in the establishment of T cell polarity following engagement to an APC.
Specificity:
Recognizes the human MARK2 protein phosphorylated at Threonine 595
Cross Reactivity:
Human, Dog, Bovine, Mouse and Rat
Host Isotype / Clone#:
Rabbit, IgG
Immunogen:
The antibody was produced against synthesized peptide corresponding to amino acids surrounding phosphorylated Thr595 of human MARK2 isoform a.
Purification:
Immunoaffinity chromatography
Stability:
1yr at –20oC from date of shipment.
Sample Data:
Western Blot of Anti-Phospho-MARK2 (Thr595) (1:500 diltuion). Lane 1: wild type Jurkat cells. Lane 2: wild type Jurkat cells stimulated with CD3/CD28 (T-cell receptor stimulation). Load: 35 µg per lane.
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References:
1. Yoshimura, Y. et.al: Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons. . J. Neurosci. 27:13098-13107, 2010.
2. Saadat, I. et.al: Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447: 330-333, 2007.
There are no related publications available for this product.
Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
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