Rabbit Polyclonal Antibody
Catalog No. P02-653R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P02-653R-100 | 100 ug | $675 | |
P02-653R-BULK | BULK | Contact Us |
Overview:
In mammals, there are several identified isoforms of p21-activated protein kinases or PAKs. PAKs 1, 2 and 3 are members of the serine/threonine p21-activating kinases that serve as targets for the small GTP binding proteins Cdc42 and RAC1. They have been implicated in wide range of biological activities, which include cytoskeletal reorganization and nuclear signaling. CDC42 and RAC1 induce autophosphorylation of PAK2, which stimulates sustained phosphorylation of other substrates (2). Autophosphorylation of Thr402 is essential for activation of PAK (Jakobi et al., 2000).
References:
1. Martin, G. A. et.al: A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14: 1970-1978, 1995. 2. Jakobi R. et al: Substrates enhance autophosphorylation and activation of p21-activated protein kinase gamma-PAK in the absence of activation loop phosphorylation. Eur J Biochem 267:4414-4421, 2000.
Specificity:
Recognizes the PAK (P21-GTPase Activated Protein Kinase)
Cross Reactivity:
Human
Host Isotype / Clone#:
Rabbit, IgG
Immunogen:
The antibody was produced against human PAK1/2/3 phospho peptide corresponding to a region in the protein conjugated to KLH.
Purification:
Immunoaffinity chromatography
Stability:
1yr at –20oC from date of shipment
BCQ Nguyen et al., Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro Drug Discovery and therapeutics May 2017 10.5582/ddt.2017.01011
Berger A et al., PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis Leukemia March 2014 10.1038/leu.2013.351
Kassardjian Ari et al., The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle PLoS One November 2012 10.1371/journal.pone.0050645
Regina Maisha et al., Use of Bionanotechnology to decipher the patterns of assemblage and interactions of multi-protein complexes not in journal August 2009
Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
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