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CHK2, Active

Recombinant full-length human CHK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. C48-10G


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Catalog No. Pack Size Price (USD)
C48-10G-05 5 ug $226
C48-10G-10 10 ug $325
C48-10G-BULK BULK Contact Us  


Overview:

CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner (1). Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization (2).


Gene Aliases:

RP11-436C9.1, CDS1, CHEK2, HuCds1, LFS2, PP1425, RAD53


Genbank Number:


References:


1. Matsuoka, S. et al: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7.

2. Chehab NH. et al: Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 2000 Feb 1;14(3):278-88.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~88 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  p53 Protein, P05-30G

  Chktide, C10-58

  Anti-CHK2, C48-60M

  CHK2, Active, C48-10H


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