AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers (1). AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92 (2). This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype.
AURKB, AIK2; AIM1; ARK2; AurB; IPL1; AIM-1; STK12
1. Shannon, K B. et al: Chromosome dynamics: new light on Aurora B kinase function. Curr Biol. 2002 Jul 9;12(13):R458-60.
2. Andrews, P. D. et al: Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6: 253-268, 2004.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
A Stützer et al., Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails. Molecular Cell January 2016 10.1016/j.molcel.2015.12.015
Liokatis Stamatios et al., Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events Nature Structural and Molecular Biology July 2012 10.1038/nsmb.2310
Han Areum et al., Methylation-mediated control of aurora kinase B and Haspin with epigenetically modified histone H3 N-terminal peptides Bioorganic & Medicinal Chemistry April 2011 10.1016/j.bmc.2011.02.011
Mandala Ranadip et al., pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner Molecular Oncology March 2013 10.1016/j.molonc.2013.11.003
Kassardjian Ari et al., The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle PLoS One November 2012 10.1371/journal.pone.0050645
Z Xingyu et al., Quercetin suppresses lung cancer growth by targeting Aurora B kinase. Cancer Med. November 2016 10.1002/cam4.891
et al., Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene- 2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors Medicinal Chemistry Research December 2016 10.1007/s00044-016-1719-3
Cancer, Cell Cycle, Ser/Thr Kinases