VEGFR, PDGFR inhibitor
Catalog No. F11-900F
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| F11-900F-05 | 5 mg | $105 | |
| F11-900F-25 | 25 mg | $420 | |
| F11-900F-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM ) (1). Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM) (2). Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease (3).
References:
1. RL Kendall et al. J. Biol. Chem. 1999 274:6453
2. L Sun et al. J. Med. Chem. 1998 41:2588
3. Schultheiss et al. Angiogenesis 2006 9:59
CAS Registry Number:
5812-07-7
Molecular Formula:
C17H16N2O
Appearance:
Orange powder
Melting Point:
N/A
Molecular Weight:
264.3
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved DMSO (25 mg/ml)
Aliases:
1. 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one
2. DMBI
Storage and Stability:
Storage, Stability and Shipping
Molecular Structure:
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There are no related publications available for this product.
Angiogenesis, Cancer, Cell Cycle, Neurobiology
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