Overview:

PP2Cα is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C alpha is known to be negative regulators of cell stress response pathways. PP2C alpha has been reported to negatively regulate TGFβ signaling pathway and cell cycle. PP2C alpha has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control (1). Overexpression of PP2C alpha is reported to cause cell-growth arrest or cell death. PP2C alpha is highly expressed in heart and skeletal muscle (2).

Gene Aliases:

PP2C-ALPHA, PPM1A, PP2CA, MGC9201, FLJ42306

Genbank Number:

NM_021003

References:

1. Parvari, R. et. al: A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease. Am. J. Hum. Genet. 69: 869-875, 2001.

2. Marley, A. E. et. al: The cloning expression and tissue distribution of human PP2C-beta.FEBS Lett. 431: 121-124, 1998.