Overview:

SUMO2 is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO2 is bound to target proteins as part of a post-translational modification system and modifies numerous cellular proteins and affect their metabolism and function. SUMO2 is also involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO2 is predominantly detected on nuclear bodies (2).

Gene Aliases:

HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A

Genbank Number:

BC008450

References:

1. Su, H.-L. et.al: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296: 65-73, 2002.

2. Kamitani, T. et.al: Characterization of a second member of the sentrin family of ubiquitin-like proteins. J. Biol. Chem. 273: 11349-11353, 1998.