Overview:

UBC9 is a member of the E2 ubiquitin-conjugating enzyme family that is involved in ubiquitin-dependent protein degradation system (1). Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UBC9 can function as a co-factor of PLAGL2, uncoupling its enzymatic activity to mediate PLAGL2 interactive SP-C promoter activity (2). UBC9 also plays an important role in the up-regulation of the bone morphogenetic protein signaling pathway.

References:

1. Yasugi, T. et.al: Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. Nucleic Acids Res. 24: 2005-2010, 1996.

2. Wang, Z.-Y. et.al: Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. J. Biol. Chem. 271: 24811-24816, 1996.