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TBK1, Active

Recombinant full-length mouse TBK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T02M-10G

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Catalog No. Pack Size Price (USD)
T02M-10G-05 5 ug $226
T02M-10G-10 10 ug $325
T02M-10G-BULK BULK Contact Us  


TBK1, also known as NAK or NFkB-activating kinase, is an upstream protein kinase that can phosphorylate and activate the IkB kinases (1). Activation of IkB kinases allows the phosphorylation of IkB protein which is then degraded via the ubiquitination pathway. This mechanism allows the activation of the NFkB transcriptional complex. TBK1 is a specific upstream regulator of IkB kinases and can also interact and the IkB protein TANK. TBK1 is a component of the virus-activated kinase that phosphorylate IRF3 and IRF7 allowing their dimerization and translocation to the nucleus, where they induce transcription of interferon (2).

Gene Aliases:


Genbank Number:


1. Tojima, Y. et al: NAK is an I-kappa-B kinase-activating kinase. Nature 404: 778-782, 2000.

2. Sharma, S. et al: Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148-1151, 2003.

Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

105 kDa

Product Datasheets

There are no related publications available for this product.


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