PAK6 is a Ser/Thr protein kinase that is a member of the PAK (p21-activated kinase) family that are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 is highly expressed in the testis and prostate tissues and interacts with the androgen receptor (AR). In response to androgen, PAK6 cotranslocate into the nucleus with AR (1). PAK6 is weakly expressed in normal prostate epithelium but the expression is increased in primary and metastatic prostate cancer cells and is further increased in tumors that relapse after androgen deprivation therapy (2).
1. Yang F, et al: Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J. Biol. Chem. 276: 15345-15353, 2001.
2. Kaur R, et al: Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate. 2008 Oct 1;68(14):1510-6.
Recognizes the PAK6 protein
Host / Isotype / Clone#:
PAK6 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK6
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Western blot analysis of PAK6 in Raji lysate with PAK6 antibody at (A) 1, (B) 2, and (C) 4 ug/ml.
Immunocytochemistry of PAK6 in Raji cells with PAK6 antibody at 10 ug/ml.
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Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases