Human active form TRAIL (114-281) was expressed in E. coli cells and purified by proprietary chromatographic techniques.
Catalog No. T880-40N
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Trail or TNF-related apoptosis inducing ligand is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family which function as prominent mediators of immune regulation and the inflammatory response. TRAIL induces significant cell death in human colon polyps and providing a potentially selective approach for colorectal cancer chemoprevention by targeting APC-deficient cells for apoptosis (1). TRAIL plays a crucial role in hepatic cell death and hepatic inflammation (2).
TL2; APO2L; CD253; Apo-2L; TNFSF10
1. Zhang, L.. et.al: Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature 464: 1058-1061, 2010.
2. Zheng, S.-J. et.al: Critical roles of TRAIL in hepatic cell death and hepatic inflammation. J. Clin. Invest. 113: 58-64, 2004.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Less than 0.1 ng/ug (IEU/ug) of TRAIL.
There are no related publications available for this product.
AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway