Overview:

ANKK1 or ankyrin repeat and kinase domain containing 1 is belongs to the Ser/Thr protein kinase family, and protein kinase superfamily that involved in signal transduction pathways (1). ANKK1 is closely linked to DRD2 gene on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene and it was determined to be located in exon 8 of ANKK1 gene where it causes a nonconservative amino acid substitution (2).

Gene Aliases:

X-kinase, PKK2, SGK288

Genbank Number:

NM_178510

References:

1. Manning, G.et.al: The protein kinase complement of the human genome. Science 298: 1912-1934, 2002.

2. Neville, M. J.et.al: Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum. Mutat. 23: 540-545, 2004.