Overview:

MATK belongs to tyrosine protein kinase family, CSK subfamily. It inactivates Src family kinase activity by specifically phosphorylating their C-terminal regulatory tyrosine residue and may plays a significant role in the signal transduction of hematopoietic cells (1). MATK binds to the phosphorylated Tyr568/570 sites on c-KIT to which FYN binds and leads to the down-regulation of FYN (2). MATK has been shown to be involved in signaling in some cases of breast cancer.

Gene Aliases:

CHK; CTK; HHYLTK; HYL; HYLTK; LSK

Genbank Number:

NM_139355

References:

1. Hirao A. et.al: Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. EMBO J. 16:2342-2351(1997).

2. Price D.J. et.al: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J. Biol. Chem. 272:5915-5920(1997).