Recombinant full-length human PIM3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P37-10BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P37-10BG-05 | 5 ug | $226 | |
P37-10BG-10 | 10 ug | $325 | |
P37-10BG-BULK | BULK | Contact Us |
Overview:
PIM3 or PIM-3 oncogene belongs to a family of protooncogenes that encode serine/threonine protein kinases (1). Pim-3 expressed in hepatocellular carcinoma development and plays a main role in the proliferation of human hepatoma cell lines (2). Pim-3 also expressed in human pancreatic cancer cell and phosphorylates BAD to block Bad-mediated apoptosis in human pancreatic cancer cell lines (3).
Gene Aliases:
PIM-3
Genbank Number:
References:
1. Mikkers, H. et.al: Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Molec. Cell. Biol. 24: 6104-6115, 2004.
2. Fujii, C. et.al: Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int. J. Cancer 114: 209-218, 2005.
3. Li, Y.-Y. et.al: Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res. 66: 6741-6747, 2006.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~65 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cellular Stress, Inflammation, Neurobiology, Ser/Thr Kinases
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