Recombinant full-length human MEK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M03-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M03-10G-05 | 5 ug | $226 | |
| M03-10G-10 | 10 ug | $325 | |
| M03-10G-BULK | BULK | Contact Us |
Overview:
MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways (1). Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation (2).
Gene Aliases:
MAP2K2, MKK2, PRKMK2, MAPKK2
Genbank Number:
References:
1. Shuichan, Xu et al: Differential Regulation of Mitogen-Activated Protein/ERK Kinase (MEK)1 and MEK2 and Activation by a Ras-Independent Mechanism. Mol. Endocrinol. 1997;11 (11): 1618-1625.
2. Louis-François, B, et al: Mek2 Is Dispensable for Mouse Growth and Development. Mol. Cellular Biol. 2003; 23 (14): 4778-4787.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~71 kDa
AS Banks et al., An ERK/Cdk5 axis controls the diabetogenic actions of PPAR[gamma] Nature January 2015 10.1038/nature13887
Joon Kim Dong et al., CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo Carcinogenesis January 2013 10.1093/carcin/bgt015
Hyun Lee Mee et al., Direct targeting of MEK1/2 and RSK2 by silybin induces cell cycle arrest and inhibits melanoma cell growth Cancer Prevention Research February 2013 10.1158/1940-6207.CAPR-12-0425
et al., Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy March 2023
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
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