Recombinant human MAPKAPK2 (46-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. M40-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M40-11G-05 | 5 ug | $226 | |
| M40-11G-10 | 10 ug | $325 | |
| M40-11G-BULK | BULK | Contact Us |
Overview:
MAPKAPK2 (MAPKAP kinase2) is a Ser/Thr protein kinase which is regulated via direct phosphorylation by p38 MAP kinase (1). In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 has been shown to be one of the substrates of MAPKAPK2 in vivo.
Gene Aliases:
(2 isoforms)
Genbank Number:
References:
1. Stokoe, D. et al: The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem. J. 296: 843-849, 1993.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
|
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
|
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~68 kDa
Williams PA et al., MAPKAP kinase 2-mediated phosphorylation of HspA1L protects male germ cells from heat stress-induced apoptosis Cell Stress Chaperones October 2019 10.1007/s12192-019-01035-6
Douglass Jacqueline et al., Identifying Protein Kinase Target Preferences Using Mass Spectrometry American Journal of Physiology - Cell Physiology June 2012 10.1152/ajpcell.00166.2012
et al., The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain Journal of Inflammation (London, England) June 2021
Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases
MAPKAPK3, Unactive, M41-14G
HSP27tide, H31-58
14-3-3 theta Protein, Y84-30G
ATP Stock Solution, A50-09
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com