Overview:

CDK11/Cyclin C is a member of the p34Cdc2 protein kinase family which are known to be essential for eukaryotic cell cycle control. CDK11/Cyclin C gene complex may harbor 1 or more tumor suppressor genes affected by chromosome 1p36 modifications in neuroblastoma (1). CDK11/Cyclin C expression is regulated during murine embryogenesis and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle (2).

Gene Aliases:

CDK11: CDC2L6; CDK8-like; bA346C16.3; KIAA1028
CyclinC: CCNC, CycC

Genbank Number:

NM_015076
NM_005190

References:

1. Lahti, J. M.. et.al: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994.

2. Bunnell, B.et.al: Elevated expression of a p58 protein kinase leads to changes in the CHO cell cycle. Proc. Nat. Acad. Sci. 87: 7467-7471, 1990. Note: Erratum: Proc. Nat. Acad. Sci. 88: 2612 only, 1991.