Overview:

IGF1R (Insulin-like Growth Factor 1) is a transmembrane tyrosine kinase receptor that is activated by IGF-1 and by the related growth factor IGF-2 (1). IGF1R mediates the effects of IGF-1 and plays an important role in growth and anabolic effects in adults. The IGF1R is implicated in several cancers, most notably breast cancer where it is highly overexpressed and functions as an anti-apoptotic agent by enhancing cell survival. In many instances, the anti-apoptotic properties of IGF1R overexpression allows cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy (2).

Gene Aliases:

CD221, IGFIR, JTK13, MGC142170, MGC142172

Genbank Number:

NM_000875

References:

1. Yaghmaie F, et al:. "Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction".. Experimental Gerontology, 2007; 42 (1-2): 148-149

2. Jones, H. et al (2004). "Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells". Endocr. Relat. Cancer, 2004 11 (4): 793-814.