Recombinant human WNK3 (1-571) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. W04-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
W04-11G-05 | 5 ug | $226 | |
W04-11G-10 | 10 ug | $325 | |
W04-11G-BULK | BULK | Contact Us |
Overview:
WNK3 is a member of serine-threonine protein kinases, which was named the with-no-lysine family (1). WNK3 is expressed in several tissues including kidney and brain (1). WNK3 can regulate the activity of the electroneutral cation-coupled chloride cotransporters by activating NKCC1/2 and NCC and inhibiting KCCs (1). WNK3 kinase function is required for normal blood pressure homeostasis and the control of neuronal excitability (2). Also, overexpression of WNK3 increases the survival of Hela cells through caspase-3 pathway (3).
Gene Aliases:
PRKWNK3; FLJ30437; FLJ42662; KIAA1566
Genbank Number:
References:
1. Rinehart J., et.al: WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl-cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci USA.; 102(46):16777-82, 2005.
2. Kahle KT., et.al: WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Proc Natl Acad Sci USA.; 102(46):16783-8, 2005.
3. Veríssimo F., et.al: Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. Oncogene, 25 (30): 4172-82, 2006.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~91 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Lipid Kinases, Neurobiology, p38 Pathway
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